Chronic Liver Disease and the Role of Non-Invasive Diagnostic Tools: Exploring the Advancements in Elastography and Biomarkers for Assessing Fibrosis and Cirrhosis
1Dr Shakir Hussain keerio, 2Dr Ikram, 3Mohib Ali, 4Dr Hadi Raza,5Dr. Muhammad Sohail Baig, 6Dr Muhammad Javed
Submission: 14 January 2026 | Acceptance: 31 January 2026 | Publication: 22 February 2026
1Assistant professor Peoples university of medical and health sciences for women’s Nawab Shah.
2University of Health Sciences (UHS), Lahore
3University of Health Sciences (UHS), Lahore
4Pakistan Institute of Medical Sciences, Islamabad
5Pakistan Institute of Medical Sciences, Islamabad
6Associate Professor Gastroenterology Department of Medicine Gajju Khan Medical College and Bacha Khan Medical Complex Shah Mansoor Swabi
Abstract:
Background: Chronic liver disease (CLD) incorporate a continuum of liver pathologies that can leads to fibrosis, hepatic failure and cirrhosis. Early observation and monitoring are mainly essential because it help to reduce disease load and improve its outcomes.The background of this study is specifically related to the chronic, elastography and some biological marks which help to solve lots of problem related to patients.
Aim: This study pursues to evaluate the effectiveness of non-intrusive diagnostic tool. We use several types of techniques which is particularly used in elastographical techniques and serum biomarkers, in evaluation of liver fibrosis and cirrhosis.
Methods: A structured review of recent publications 2016-2022 was conducted, its main focus is on studies to calculate transient electrography, magnetic resonance electrography known as MRE, serum biomarkers like Fibro Test, APRI, and FIB-4 and acoustic radiation force impulse imaging.
Results: Elastography methods show high sensitivity and specificity in detecting significant cirrhosis and fibrosis. Biological markers provide interdependent value but with various accuracy which is based on aetiology. Combine approach the method to improve diagnostic accuracy. Accuracy and precision both depends upon the working and treatment.
Conclusion: Non-intrusive diagnostics, especially elastographical which is combined with serum markers which offers a reliable, safety alternatives and to liver biopsy for co-ordination of cirrhosis and liver fibrosis.
Keywords: mobidity, spectrum,cirrhosis,fibrosis.